p16INK4A and p15INK4B gene deletions in primary leukemias
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چکیده
منابع مشابه
Gene Expression Status and Methylation Pattern in Promoter of P15INK4b and P16INK4a in Cord Blood CD34+ Stem Cells
Objective(s): Stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including P15INK4b and P16INK4a genes. Epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure. Materials and Methods: The CD34 + cord blood s...
متن کاملBrief report p16INK4a and p15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance
p15INK4b and p16INK4a proteins are cell cycle regulators involved in the inhibition of G1 phase progression. High frequency of methylation of both genes has been reported in multiple myeloma (MM), but it remains to be determined how and when these alterations contribute to tumorigenesis. Monoclonal gammopathy of undetermined significance (MGUS) represents an early disease stage in a fraction of...
متن کاملgene expression status and methylation pattern in promoter of p15ink4b and p16ink4a in cord blood cd34+ stem cells
objective(s): stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including p15ink4b and p16ink4a genes. epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure. materials and methods: the cd34 + cord blood stem cells were pu...
متن کاملNEOPLASIA Acquisition of p16INK4A and p15INK4B Gene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia
Although numerous somatic mutations that contribute to the pathogenesis of childhood acute lymphoblastic leukemia (ALL) have been identified, no specific cytogenetic or molecular abnormalities are known to be consistently associated with relapse. The p16INK4A (p16), which encodes for both p16INK4A and p19ARF proteins, and p15INK4B (p15) genes are inactivated by homozygous deletion and/or p15 pr...
متن کاملGene Expression Status and Methylation Pattern in Promoter of P15INK4b and P16INK4a in Cord Blood CD34+ Stem Cells
Objective(s) : Stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including P15INK4b and P16INK4a genes. Epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure. Materials and Methods : The CD34 + cord blood stem cells were pu...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.1.311.bloodjournal861311